Case study
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June 16, 2025
Solid-Phase Synthesis of Macrocyclic Peptide
BioDuro' s peptide chemistry team successfully completed a highly challenging 37-step solid-phase synthesis of I-66 acetate in just 6 weeks, delivering 50 mg of the final compound. This remarkable achievement highlights our deep expertise in tackling intricate peptide chemistry, particularly in the synthesis of multi-cyclic and constrained peptides.
Key Highlights
- Precision palladium-catalyzed orthogonal deprotection
- Strategic dual ring-closing metathesis (RCM) with advanced catalysts
- Systematic multi-cyclization design on solid phase
This breakthrough demonstrates BioDuro' s capacity to overcome highly complex synthetic challenges and deliver high-purity peptides against demanding timelines.
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