Large Molecule Development and Bioanalysis
Integrated large molecule bioanalysis and DMPK services supporting biologics, peptides, proteins, antibody-drug conjugates (ADCs), and other complex therapeutic modalities throughout discovery and preclinical development.
BioDuro combines advanced bioanalytical workflows, immunoassay platforms, high-resolution mass spectrometry, and integrated DMPK expertise to help characterize exposure, stability, metabolism, and pharmacokinetic behavior across large molecule programs.
Quantitative Bioanalysis
Robust analytical approaches supporting PK, PD, TK, and biomarker analysis across discovery and preclinical studies.
- LC-MS/MS and LC-HRMS analysis
- Ligand binding assays (LBA)
- PK, PD, and TK bioanalysis
- Biomarker evaluation support
Molecular Characterization
Analytical characterization capabilities designed to evaluate biologic structures, metabolites, and degradation pathways.
- Protein and peptide characterization
- Metabolite profiling
- Structural characterization workflows
- Stability and degradation assessment
Discovery Collaboration
Bioanalytical scientists work closely with DMPK, biology, and discovery teams to help interpret data and guide program progression across complex modality programs.
- Peptides and proteins
- ADCs and oligonucleotides
- Flexible study support
- Rapid turnaround timelines
Gyrolab Automated Immunoassays
High-sensitivity ligand-binding assays supporting protein, antibody, ADC, and biomarker quantification with minimal sample volume requirements.
LC-MS/MS Analysis
Mass spectrometry-based approaches supporting quantitative bioanalysis, payload analysis, metabolite characterization, and complex modality evaluation.
Meso Scale Discovery (MSD)
Electrochemiluminescence immunoassay platforms supporting PK, ADA, biomarker, and large molecule bioanalysis studies.
PCR-Based Bioanalysis
Molecular biology methods supporting oligonucleotide, ASO, and siRNA bioanalysis workflows.
Decoding ADC ADME with Tailored Strategies
Antibody-drug conjugates present unique pharmacokinetic, metabolism, and bioanalytical challenges that often require specialized development approaches. Download this flyer to explore key ADME considerations, bioanalytical strategies, and integrated DMPK solutions designed to support ADC programs from discovery through development.
