Antibody–drug conjugates require precise process control to maintain full biological function. This case study demonstrates BioDuro's rapid Gram-scale bioconjugation, delivering high-quality material with preserved antibody affinity and unaffected payload potency.

Key Highlights

• Gram-Scale Bioconjugation: Reliable scale-up from milligram pilots to gram-level production with controlled DAR and structural consistency.
• Affinity Preservation: Conjugation conditions designed to maintain antibody binding performance comparable to the naked antibody.
• Payload Potency Maintenance: Process and purification steps that safeguard linker–payload integrity so cytotoxic activity remains unchanged.
• Product Quality & Safety: High monomer purity and ultra-low free-drug levels achieved through robust purification, supporting downstream studies.

Download the full case study to learn how we scale ADCs without compromising quality, potency, or timeline.