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Bioanalytical Services

Reliable bioanalytical data supporting pharmacokinetic, biomarker, and metabolism studies across discovery and preclinical development.

Combining advanced mass spectrometry, ligand binding assays, and specialized analytical expertise, BioDuro supports bioanalytical studies across small molecules, biologics, peptides, ADCs, oligonucleotides, and other complex therapeutic modalities.

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Bioanalytical Expertise Across Drug Discovery

Accurate bioanalytical measurements are essential for understanding exposure, target engagement, metabolism, and biological activity. Our scientists develop fit-for-purpose analytical strategies that help teams answer key questions throughout drug discovery and development.

LC-MS/MS Quantitation

Sensitive and reproducible quantitative analysis supporting PK, TK, biomarker, and metabolite evaluation across discovery studies.

  • LC-MS/MS method development
  • Quantitative bioanalysis
  • Biomarker analysis
  • Regulatory-ready reporting

Large & Small Molecule Support

Capabilities supporting diverse therapeutic modalities across discovery and preclinical development.

  • Small molecules
  • Peptides and proteins
  • ADCs and oligonucleotides
  • Biomarkers and metabolites

Discovery Through IND-Enabling Support

Supporting programs at every stage with scalable analytical strategies, rapid study initiation, and close collaboration across DMPK, biology, and chemistry teams.

  • Discovery support
  • IND-enabling support
  • Cross-functional scientific collaboration
  • Flexible study design

Core Bioanalytical Capabilities

Our bioanalytical laboratories are equipped with advanced mass spectrometry, immunoassay, and automation platforms that support both routine sample analysis and complex characterization studies.

Quantitative LC-MS/MS Analysis

Sensitive analytical methods supporting pharmacokinetic, toxicokinetic, and biomarker analysis.

Ligand Binding Assays (LBA)

Flexible immunoassay platforms supporting biologics, peptides, antibodies, and protein quantitation workflows.

Metabolite Identification & Profiling

Capabilities supporting structural characterization, metabolite profiling, and pathway analysis across discovery programs.

Large Molecule Bioanalysis

Bioanalytical support for biologics and complex therapeutic modalities including proteins, peptides, ADCs, and oligonucleotides.

Bioanalytical Platforms

BioDuro utilizes advanced analytical and bioanalytical technologies to support sensitive detection, molecular characterization, metabolite profiling, and quantitative analysis across small and large molecule programs.

SCIEX Triple Quad 7500

High-sensitivity LC-MS/MS analysis supporting quantitative bioanalysis for PK, PD, and TK studies.

Thermo Q Exactive Plus

High-resolution mass spectrometry supporting metabolite identification and structural characterization workflows.

Gyrolab xPlore

Automated immunoassay platform supporting sensitive large molecule bioanalysis and biomarker evaluation.

Tecan Fluent 780

Automated liquid handling platform supporting high-throughput sample preparation and bioanalytical workflows.

Featured Case Studies

Explore real-world examples of how bioanalytical and DMPK expertise supports complex therapeutic programs, from siRNA quantification to ADC characterization.

Fluorescent PNA Probe LC-FL Technology for siRNA Quantification

Learn how BioDuro developed a sensitive LC-FL bioanalytical approach for quantifying siRNA therapeutics in biological samples. This case study highlights the use of fluorescent PNA probe technology to support pharmacokinetic evaluation, tissue distribution studies, and faster bioanalytical workflows.

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T-DM1 DAR Analysis Using UPLC-HRMS

Discover how high-resolution mass spectrometry can be used to characterize drug-to-antibody ratio distribution and support the development of antibody-drug conjugates.

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DMPK Resources

Discover practical insights, application examples, and scientific expertise across drug metabolism, pharmacokinetics, bioanalysis, and preclinical development to support faster, data-driven decision-making.

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Regulatory Considerations for Nonclinical Study of ADCs ADME
Whitepaper DMPK

Regulatory Considerations for Nonclinical Study of ADCs: ADME Strategy & Experimental Approaches

Explores regulatory considerations for ADC ADME studies, highlighting BioDuro's integrated strategy for PK, DDI, and biotransformation evaluation....
Hit to PCC in 16 Months
Case study Biology Chemistry DMPK

Integrated Drug Discovery (IDD): Hit to PCC in 16 Months

Discover how BioDuro' s integrated drug discovery platform accelerated a novel kinase inhibitor for inflammatory disease from initial hit identification to...

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DMPK & Bioanalytical Services

BioDuro provides DMPK, bioanalytical, and characterization capabilities supporting discovery and preclinical programs across small molecules and complex therapeutic modalities.

Peptide DMPK Large Molecule Development and Bioanalysis Toxicity In Rodents, Dogs and Monkeys In Vitro ADME In Vivo PK and TK