Antibody-Drug Conjugate
BioDuro combines antibody discovery, payload and linker chemistry, bioconjugation, pharmacology, and DMPK expertise to help advance ADC candidates from concept through preclinical evaluation.
Payload & Linker Design
Optimize ADC stability and therapeutic performance
Payload synthesis, SAR optimization, linker development, and payload-linker strategies designed to improve efficacy, stability, and delivery.
Bioconjugation & ADC Engineering
Build and characterize ADC candidates
Conjugation workflows spanning traditional and site-specific approaches, supported by analytical characterization and ADC evaluation capabilities.
Pharmacology & DMPK Evaluation
Generate translational insights
In vitro, in vivo, and bioanalytical studies designed to evaluate efficacy, pharmacokinetics, stability, DAR, and developability.
Case Study: Optimizing and Shortening a Payload-Linker Synthesis Route
Working closely with each program’s unique requirements, BioDuro’s ADC chemistry teams routinely evaluate and refine published synthetic methods to improve efficiency and support project goals.
For the synthesis of Int-A, multiple literature routes were reviewed to identify opportunities for process optimization. The revised synthetic strategy shortened the reaction cycle while also generating a product that was easier to purify, helping accelerate downstream development activities.
Payload & Linker Development
- Payload synthesis for targeted therapeutics
- Cleavable and non-cleavable linker strategies
- Payload-linker synthesis and optimization
Conjugation & Evaluation
- Bioconjugation workflows
- PK and bioanalysis studies
- In vitro and in vivo evaluation
- Preclinical characterization support
