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Connected expertise from oligonucleotide design to exposure

Oligonucleotide discovery platform

At BioDuro, oligonucleotide chemistry and conjugation form the core of our offering, supported by biology and bioanalysis for candidate and exposure assessment.Our capabilities span modified oligonucleotide design and synthesis, conjugate generation, candidate evaluation, and PK studies.

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Connected capabilities across the oligonucleotide workflow

Oligonucleotide chemistry and synthesis

Support modified nucleoside and oligonucleotide design, synthesis, purification, and characterization from discovery libraries through gram-scale custom synthesis.

Oligonucleotide conjugation

Customize, construct, purify, and characterize ligand-, lipid-, peptide-, and antibody–oligonucleotide conjugates.

Oligonucleotide biology and candidate evaluation

Compare candidates across gene regulation, protein response, selectivity, cellular uptake, stability, and early immune response.

Oligonucleotide bioanalysis and DMPK

Quantify oligonucleotide exposure across plasma and tissues using oligonucleotide-specific bioanalysis connected with PK study execution.

Oligonucleotide chemistry

BioDuro supports modified oligonucleotide programs from early library generation through gram-scale custom synthesis. Chemistry design, synthesis, purification, and analytical characterization can be tailored to the sequence, modification, and material requirements of each program.

Key Capabilities

  • Modified nucleosides, phosphoramidites, and complex building blocks
  • Nucleobase, ribose, and backbone modifications
  • ASO, siRNA, and long-oligonucleotide synthesis
  • Oligonucleotide libraries, tox batches, and gram-scale custom synthesis
  • Purification and analytical characterization

Oligonucleotide conjugation

BioDuro’s oligonucleotide conjugate chemistry encompasses constructs that link oligonucleotides with ligands, lipids, peptides, or antibodies. Formats include GalNAc conjugates, PPMO, antibody–oligonucleotide conjugates, and bispecific constructs, supported by conjugate-specific purification and characterization.

Key Capabilities

  • Ligand-, lipid-, peptide-, and antibody-linked oligonucleotide formats
  • Oligonucleotide, linker, and targeting component customization
  • Conjugate purification
  • Characterization of mass, purity, free oligonucleotide, and loading ratio

Oligonucleotide biology

Gene-regulation activity alone does not establish whether an oligonucleotide candidate produces the intended protein response, maintains selectivity, reaches cells effectively, or has suitable stability and early immune-response profiles.

BioDuro connects functional and developability assessments to compare candidates across these dimensions and support informed selection decisions.

Key Capabilities

  • mRNA-level gene-regulation assessment
  • Protein-level response and functional confirmation
  • Mechanism and selectivity assessment, including on- and off-target screening
  • Cellular uptake and delivery evaluation
  • Developability assessment covering thermal and nuclease stability and early immune response

Oligonucleotide DMPK

BioDuro addresses sequence- and matrix-specific bioanalytical challenges to quantify oligonucleotides in plasma and tissues, supporting the interpretation of systemic exposure and tissue distribution in PK studies.

Key Capabilities

  • LC-MS/MS and PNA-hybridization LC-fluorescence bioanalysis
  • Sequence-selective method development and performance assessment
  • Matrix-appropriate sample processing
  • Plasma, liver, and kidney bioanalysis
  • PK study execution, exposure profiling, and PK parameter assessment

Related Resources

Explore how BioDuro developed and characterized antibody–oligonucleotide conjugates with controlled oligonucleotide-to-antibody ratios, high purity, and preserved antibody integrity.

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Antibody oligonucleotide conjugate synthesis for controlled oars
Case study Chemistry

Antibody-Oligonucleotide Conjugate – Synthesis for Controlled OARs

This case study highlights a successful AOC development program that overcame the inherent complexity of these large, charged, and structure sensitive molecule...

Looking for an Oligonucleotide Discovery Partner?

Whether you’re designing modified oligonucleotides, developing conjugates, evaluating candidates, or advancing into PK studies, BioDuro’s connected oligonucleotide platform can help move your program forward.

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