Analytical Chemistry

From purification and rigorous characterization to analysis and structure confirmation, BioDuro’s analytical chemistry team works closely with synthetic chemists to ensure the quality of synthesized compounds and support rapid project turnaround.

Analytical Chemistry That Keeps Discovery Moving

Upon completion of synthesis, compounds undergo purification, characterization, analysis, and structure confirmation by BioDuro’s analytical chemistry team. Our analytical scientists work closely with synthetic chemists and project teams, allowing analytical needs to be addressed quickly as projects progress.

With extensive in-house instrumentation and automation, our experienced analytical team provides reliable, reproducible data with the flexibility and fast turnaround needed for discovery chemistry programs.

Analytical Chemistry Services

Our analytical chemistry team provides a range of services for compound purification, characterization, and analysis.

Method Development

Analytical method development tailored to the compound and specific needs of each project.

Routine Purification

Purification of synthesized compounds using established chromatographic and separation techniques.

Chiral Separation

Analytical and semi-preparative chiral separation for the analysis and purification of enantiomers.

Impurity Analysis

Analysis and characterization of impurities to help assess compound purity and quality.

Thermal Analysis

Thermal characterization using differential scanning calorimetry (DSC).

Particle Characterization

Determination of particle size, shape, and crystallinity.

Chromatography Separation

  • Reverse-phase chromatography by HPLC and UPLC
  • Chiral separation
  • Analytical and semi-preparative SFC

Mass Spectrometry & Structure Confirmatio

  • LC-MS analysis
  • GC-MS analysis
  • NMR analysis: ¹H, ¹³C, ¹⁹F, and ³¹P nuclei
  • 1D and 2D NMR experiments
  • Optical rotation determination

Physicochemical & Stability Testing

  • Dissolution
  • Karl Fischer
  • Stability testing
  • Physicochemical property testing according to USP and CHP
  • Residual solvent determination by GC-FID and ECD
  • Particle size, shape, and crystallinity determination
  • Thermal analysis by DSC

Analytical & Purification Instrumentation

More than 100 analytical and purification instruments, including LC-MS, HPLC/UPLC, and GC-MS systems from Agilent, Shimadzu, and Waters, provide broad in-house capacity for compound analysis and purification.

High-Throughput Purification

BioDuro’s purification capacity exceeds 500 samples per day, providing the throughput needed for larger discovery chemistry programs.

Chiral Separation & Purification

BioDuro has 10 chiral separation instruments, including chiral HPLC and SFC systems from Thar, Waters, and Shimadzu.

The in-house chiral column collection includes 20+ analytical and 20+ semi-preparative phases, providing options for a broad range of chiral separations.

Why Teams Work With BioDuro

  • Dedicated team of trained analytical chemists
  • Close interaction with synthetic chemists and project teams
  • Flexible support based on project needs
  • Fast turnaround time
  • Reproducible, high-quality data