Sugar Chemistry
Carbohydrate synthesis can be challenging, particularly when managing complex molecular structures, controlling stereochemistry, and working with sensitive compounds.
BioDuro brings experience in monosaccharide and oligosaccharide synthesis, process optimization, and large-scale production. Our scientists develop efficient synthetic routes, improve yields, and address purification challenges to support projects from development through manufacturing.
Monosaccharide and Oligosaccharide Synthesis
BioDuro has experience synthesizing carbohydrate building blocks derived from mannose, arabinose, fucose, rhamnose, glucosamine, and galactose. Our expertise also includes complex oligosaccharides, such as hexasaccharide linkers, with demonstrated production of selected monosaccharide derivatives at scales reaching several hundred kilograms.
Glycan Building Blocks for ADCs
BioDuro synthesizes glycan building blocks for glycosite-specific antibody-drug conjugates (ADCs), including dual-payload applications. Our experience includes high-mannose and sialyl-type glycans, with synthesis demonstrated at scales ranging from 100 grams to more than 10 kilograms.
Process Development and Optimization
Our scientists optimize multistep synthetic routes to improve yields, control impurities, and reduce production costs. Our expertise covers route optimization, reducing reaction steps, isomer control, process demonstration, and technology transfer to manufacturing facilities.
Purification and Impurity Control
BioDuro develops isolation and purification methods for complex carbohydrate synthesis. Our experience includes reducing or eliminating column chromatography where appropriate, establishing in-process controls, and developing purification methods to manage impurities and maintain product quality.
