Fluorescent PNA Probe LC-FL Technology for siRNA Quantification

Discover how BioDuro’ s innovative bioanalytical technology overcomes critical challenges in quantifying siRNA therapeutics. This case study highlights our breakthrough approach for precise, sensitive quantification of Givosiran—an FDA-approved siRNA drug—accelerating PK and tissue distribution studies in preclinical development.

Key Highlights

  • Novel Quantification Method: Leverages proprietary technology for enhanced sensitivity and selectivity.
  • Streamlined Workflow: Reduces analysis time by 40% and improves sensitivity 5x versus traditional methods.
  • Cross-Tissue Application: Successfully quantified siRNA in plasma, liver, and kidney samples from mouse PK studies.
  • Efficiency-Driven: Simplifies sample processing and supports high-throughput workflows for faster drug discovery.

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