Case study
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June 17, 2025
Fluorescent PNA Probe LC-FL Technology for siRNA Quantification
Discover how BioDuro’ s innovative bioanalytical technology overcomes critical challenges in quantifying siRNA therapeutics. This case study highlights our breakthrough approach for precise, sensitive quantification of Givosiran—an FDA-approved siRNA drug—accelerating PK and tissue distribution studies in preclinical development.
Key Highlights
- Novel Quantification Method: Leverages proprietary technology for enhanced sensitivity and selectivity.
- Streamlined Workflow: Reduces analysis time by 40% and improves sensitivity 5x versus traditional methods.
- Cross-Tissue Application: Successfully quantified siRNA in plasma, liver, and kidney samples from mouse PK studies.
- Efficiency-Driven: Simplifies sample processing and supports high-throughput workflows for faster drug discovery.
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