Case study
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July 15, 2025
T-DM1 DAR analysis in HER2-positive tumor-bearing mouse plasma using UPLC/HRMS
Discover how UPLC/ HRMS delivers critical insights into the changing DAR of T-DM1 in HER2-positive tumor models. This case study reveals a streamlined approach to monitor DAR distribution shifts in mouse plasma over time—directly linking to ADC efficacy and safety.
Key Highlights
- Critical ADC Behavior: Observe dynamic DAR shifts in live tumor-bearing mice post-dosing.
- Efficient Workflow: Leverage advanced analytics requiring minimal sample processing.
- Translation-Ready: Gain a validated method to assess ADC performance in preclinical models.
Decoding DAR dynamics empowers ADC developers to de-risk development and maximize therapeutic outcomes.
To explore these ADC insights in depth, download the full case study.
