Peptide Synthesis & Discovery Services

Services CMC Peptide Chemistry

BioDuro supports peptide programs ranging from linear sequences to complex cyclic, modified, and conjugated peptides. Synthesis and purification strategies are developed around the structure of the peptide, required quantity, target purity, and intended use.

Capabilities include solid-phase peptide synthesis (SPPS), liquid-phase peptide synthesis (LPPS), cyclization, specialized modifications, conjugation, purification, process development, and scale-up.

More information?

Peptide Synthesis Expertise

Peptide synthesis can become increasingly challenging as sequences grow longer or incorporate hydrophobic regions, unnatural amino acids, structural constraints, or specialized modifications.

BioDuro works with both standard and complex peptides, selecting the synthesis and purification approach based on the needs of each molecule. Capabilities include linear peptides up to 70 amino acids, including hindered unnatural amino acids, as well as cyclic and macrocyclic peptides, modified peptides, and peptide conjugates.

A dedicated 1,500 m² peptide synthesis center in Beijing is supported by a team of 100+ experienced chemists.

Peptide Modalities and Modifications

BioDuro supports a wide range of peptide structures, modifications, and conjugates for discovery and development programs.

Linear Peptides

Peptides up to 70 amino acids
Natural and unnatural amino acids
Hindered and difficult sequences
Hydrophobic peptides
Cell-penetrating peptides
TFA, acetate, and HCl salt forms

Cyclic and Macrocyclic Peptides

Lactam-cyclized peptides
Thioether-cyclized peptides
Stapled peptides
Multiple disulfide bonds
Click-chemistry cyclization
Cyclic lipopeptides

Modified and Special Peptides

N- and C-terminal modifications
Dye and fluorescent labeling
Glycosylation
Phosphorylation
PEGylation
Lipidation
Peptidomimetics
Peptoids and depsipeptides

Peptides Conjugates

Peptide drug conjugates
Metal-chelating conjugates
Linker and payload conjugation
Modified and multifunctional peptide constructs

Support across every stage of discovery.

BioDuro offers a full suite of medicinal chemistry services, including:

Hit Identification

The process of finding compounds that interact with a biological target, such as a protein.

Hit to Lead

Through evaluation and modification of “hit” compounds to enhance their potential.

Lead Optimization

Further refinement of a compound’s properties to develop a drug candidate.

Patent filing support

Guidance through the patent filing process for new drug compounds.

Solid-Phase and Liquid-Phase Peptide Synthesis

BioDuro offers both solid-phase peptide synthesis and liquid-phase peptide synthesis, allowing the development approach to be selected around peptide complexity, quantity, and scale-up requirements.

Solid-phase peptide synthesis capabilities extend to 800 mmol and support linear peptides, cyclic peptides, and peptide drug conjugates. Liquid-phase peptide synthesis is also available for projects where it provides a practical route to larger-scale production.

Purity and Product Options

Peptide purity requirements vary depending on whether the material will be used for initial research, biological testing, analytical standards, or later-stage development.

BioDuro offers peptide products at purity targets such as greater than 90%, 95%, and 98%, depending on sequence, complexity, scale, and intended application. Available product options include multiple salt forms and a broad range of modifications and conjugates.

Final specifications and timelines are established after reviewing the peptide sequence, required quantity, target purity, modifications, and analytical requirements.

Connected Peptide Development Services

Peptide programs can also draw on BioDuro’s Biology, DMPK, and Formulation capabilities. This allows synthesized peptides to move into biochemical and cellular testing, in vivo evaluation, developability assessment, and oral peptide formulation work when required.

BioDuro’s formulation team also supports oral peptide delivery approaches, including enteric coating and permeability-enhancement strategies.

Key instruments

Complex synthesis requires more than just standard protocols. See how our chemists navigate multi-step challenges to deliver high-purity compounds where standard solid-phase methods often fail.

PTI Symphony X

0.1-0.2 mmol
N2 protection
24 channels

CEM MultiPep2

0.1-0.2 mmol
N2 protection
24 channels

Tetras Volo

0.1-0.2 mmol
N2 protection
24 channels

DL-PSI-286

0.1-0.2 mmol
N2 protection
24 channels

Common Questions

In id sit nullam lorem pharetra scelerisque. Donec enim ac aliquet metus at nullam. Dignissim odio eget fermentum quam.

Get in contact

What is medicinal chemistry and how does it fit into the drug discovery process?

How are BioDuro’s medicinal chemistry services integrated with other offerings?

Can BioDuro support medicinal chemistry projects at every stage of drug development?

Medicinal chemistry involves designing and optimizing drug molecules to ensure that compounds are safe and effective before advancing in the development process.

Download our full Medicinal Chemistry Fact Sheet

In posuere at eget vestibulum mi magnis cursus nulla. Massa viverra amet eget facilisis. Morbi morbi nulla sit amet lorem augue tortor.

Download sheet

Parallel Synthesis Services

BioDuro offers synthesis and purification services to deliver both small and large libraries, with expertise to overcome discovery stage challenges and capacity for process scale-up of drug substance.

Small libraries

10 – 50mg of each compound
Purity – ≥90% (95% if desired) by HPLC/LC-MS for all compounds
1H-NMR for 5- 10% (or more, if required) of the compounds

Large libraries

10mg of each compound
Purity – ≥85% by (90% if desired) HPLC/LC-MS for all compounds
In general 1H-NMR for 5 – 10% of the compounds

Success in Action

Complex synthesis requires more than just standard protocols. See how our chemists navigate multi-step challenges to deliver high-purity compounds where standard solid-phase methods often fail.

42-Step Liquid-Phase Synthesis: Achieving 99% Purity

Challenge: Synthesizing the reference peptide MK-0616. Solution: Our team deployed a specialized liquid-phase strategy to overcome aggregation issues, delivering the target at >99% purity.

Download case study

42-Step Liquid-Phase Synthesis: Achieving 99% Purity

Challenge: Synthesizing the reference peptide MK-0616. Solution: Our team deployed a specialized liquid-phase strategy to overcome aggregation issues, delivering the target at >99% purity.

Download case study

Related Resources

Id quam odio lectus risus massa praesent. At ac quisque nec et proin adipiscing egestas proin quis. Semper id odio arcu ut augue et sagittis.

See all resources

Partnership solutions

Flexible ways to engage our chemistry teams

Integrated Drug Discovery (IDD)

Strategic leadership from target to candidate.

Let our project leaders drive the full DMTA cycle. We coordinate chemistry, biology, and DMPK to accelerate your path from Hit to PCC.

Learn more

Functional Service Provider (FSP)

Dedicated scientists working exclusively on your systems.

Extend your internal capacity with a dedicated team of BioDuro-Sundia chemists working exclusively on your projects and systems.

Learn more

IND-Enabling Programs

A complete safety & tox package for regulatory submission.

streamlined transition from PCC to IND. We combine GLP-tox batch synthesis with safety assessment to get you regulatory-ready in record time.

Learn more

Integrated Chemistry Services

Accelerate your discovery cycles by leveraging our full spectrum of chemistry capabilities. Whether you need parallel synthesis for library generation or computational insights for scaffold hopping, these integrated services act as force multipliers for your medicinal chemistry program.

Peptide Process R&D QA & EHS RSM and Intermediates Kilo and Pilot Scale API High Potency API GMP API Manufacturing API Manufacturing Drug Substance Manufacturing Pre-formulation Formulation Development Stability Studies QC Testing & Release Route Scouting & Optimization Process Safety Assessment Preparative Purification Capacity Sugar Chemistry Flow Chemistry Process R&D