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In Vivo PK & TK

Comprehensive in vivo pharmacokinetic and toxicokinetic studies supporting compound optimization, dose selection, and preclinical development across small and large molecule programs.

BioDuro expertise include rodent and non-rodent PK/TK studies with flexible study design, rapid turnaround timelines, and extensive species availability to help teams better understand compound exposure, distribution, metabolism, and safety profiles during drug discovery and development.

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In Vivo PK & TK Studies

BioDuro performs in vivo pharmacokinetic and toxicokinetic studies to characterize compound exposure, disposition, and elimination throughout discovery and preclinical development.

Studies are conducted in rodent and non-rodent species using flexible protocols, multiple dosing routes, and comprehensive biological matrix collection to generate data that supports candidate selection, dose optimization, and safety assessment.

Rodent & Non-Rodent Studies

In vivo PK/TK studies across rodent and non-rodent species.

  • PK/PD evaluation
  • Excretion pathway analysis

Administration & Sampling Capabilities

Multiple administration routes and biological matrix sampling for pharmacokinetic evaluation.

  • Tissue distribution studies
  • Biliary and urinary excretion analysis

Rapid Study Turnaround

Fast in vivo PK/TK study execution aligned with discovery timelines.

  • Typical 5-day PK studies
  • Rodent and non-rodent models

In Vivo PK & TK Capabilities

BioDuro provides pharmacokinetic and toxicokinetic studies designed to generate in vivo exposure and disposition data across discovery and preclinical programs.

Pharmacokinetic (PK) Studies

Studies evaluating absorption, distribution, metabolism, and excretion across multiple dosing strategies and species.

Toxicokinetic (TK) Studies

Toxicokinetic evaluation supporting dose-ranging and exploratory toxicology studies.

Tissue Distribution & Excretion

Capabilities supporting tissue distribution analysis and biliary or urinary excretion evaluation.

PK/PD Evaluation

Integrated pharmacokinetic and pharmacodynamic studies supporting dose and exposure assessment.

Frequently Asked Questions

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Download the In Vivo PK/TK Overview

Explore BioDuro’s in vivo pharmacokinetic and toxicokinetic capabilities across rodent and non-rodent species, including PK/PD evaluation, excretion studies, and biological matrix sampling.

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Study Design & Sampling

Flexible in vivo PK/TK studies across rodent and non-rodent species with multiple administration routes, surgical techniques, and biological matrix sampling for discovery and preclinical development.

Rodent PK/TK Studies

  • Mouse, rat, hamster, and guinea pig models
  • Serial bleeding studies
  • Single and cassette dosing (up to 5-in-1)
  • PK/PD and excretion pathway evaluation
  • Plasma, serum, tissue, bile, and CSF sampling

Large Animal PK/TK Studies

  • Dog, monkey, rabbit, mini-pig, and ferret models
  • Oral, IV, IM, SC, and specialized administration routes
  • Crossover and non-crossover study design
  • Serial CSF and biological matrix sampling
  • Exploratory toxicity and TK evaluation

Related Resources

Discover resources showcasing BioDuro’s in vivo PK/TK capabilities, including pharmacokinetic studies, bioanalytical support, and integrated DMPK solutions. These materials demonstrate approaches used to characterize compound exposure, disposition, and safety throughout drug discovery and development.

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Quantification of DS-8201a and its pharmacokinetics in mouse plasma
Case study DMPK

Quantification of DS-8201a and its pharmacokinetics in mouse plasma using Gyrolab LBA/ELISA

This case study demonstrates the successful quantification of the novel antibody-drug conjugate DS-8201a (T-DXd) in mouse plasma using Gyrolab LBA/ELISA—an ad...
Rapid Formulation Development of Amorphous Solid Dispersions
Flyer DMPK Drug Product

Rapid Formulation Development of Amorphous Solid Dispersions by Combined In-Silico Modeling, High-Throughput Screening and In-Vivo PK Study

Discover how BioDuro's innovative formulation platform accelerates the development of Amorphous Solid Dispersions (ASDs) to enhance drug solubility and bio...

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In Vivo PK/TK Services

Generate in vivo pharmacokinetic and toxicokinetic data across rodent and non-rodent studies to evaluate compound exposure, dosing strategies, and preclinical behavior.

Peptide DMPK Large Molecule Development and Bioanalysis Toxicity In Rodents, Dogs and Monkeys Bioanalytical Service In Vitro ADME