Case study
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July 15, 2025
Summary
Quantification of DS-8201a and its pharmacokinetics in mouse plasma using Gyrolab LBA/ELISA
This case study demonstrates the successful quantification of the novel antibody-drug conjugate DS-8201a (T-DXd) in mouse plasma using Gyrolab LBA/ELISA—an advanced automated immunoassay platform. Witness how minimal plasma volumes enabled robust PK profiling—delivering high-precision data consistent with established literature.
Key Highlights
- Efficient Workflow: Serial blood sampling from just 3 mice generated a complete 28-day PK profile.
- Platform Power: Gyrolab® technology delivered sensitive quantification of total antibody and ADC.
- Real-World Validation: Results confirmed DS-8201a' s slow elimination and favorable PK properties in vivo.
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