A compound's lipophilicity (LogP/LogD) is crucial for successful drug development, yet traditional methods often fail for complex 'beyond Rule of Five' (bRo5) entities like PROTACs and peptides. This article outlines an integrated, validated chromatographic strategy for accurate, high-throughput LogP and LogD determination from lead optimization to development, overcoming the limitations of shake flask assays.

Key Highlights

• Comprehensive DMPK Solutions: Our one-stop services provide superior LogP and LogD data for both Rule of Five (Ro5) compounds and challenging bRo5 entities.
• Case Studies: Demonstrated reliability with Ro5 compounds (R²=0.96 for LogD) and enhanced accuracy for bRo5 molecules (PROTACs/peptides) compared to traditional methods.
• Risk Assessment Framework: A validated chromatographic approach used to de-risk complex bRo5 entities, ensuring more reproducible results and accelerating the optimization of viable drug candidates.

For complete methodology details and implementation case studies, please download the full case study.