BioDuro supports the success of simple and complex peptide drug discovery programs. Our team specializes in process development support for various peptide forms and offers expertise in multiple purification techniques. These peptides include linear, cyclic, branched, and peptide drug conjugates (PDCs).
Case Study: BioDuro’s peptide chemistry team has advanced the development of DNA-encoded peptide libraries (DELs) by establishing robust, high-throughput synthetic platforms that enable the construction of diverse, macrocyclic peptide libraries with enhanced chemical flexibility. This work demonstrates BioDuro’s ability to overcome key limitations in DEL peptide discovery through innovative on-DNA chemistry, automation, and macrocyclization strategies.
AI assisted virtual screening (by Atombeat): Rapid filtering based on key developability traits such as membrane permeability, advancing only the most promising compounds
High-throughput synthesis: Parallel production of hundreds of peptides within one week
Without purification steps: High-purity peptides delivered directly
Seamless to biology: Direct transition from in silico design to biology assays for rapid validation
Over 17 years of extensive experience in peptide chemistry, including both solution and solid-phase synthesis
In-house synthesis of unnatural amino acids, ranging from gram to kilogram scale, using robust methods
Expertise in backbone and side chain modification of peptides
Synthesis of macro cyclopeptides with diverse structures, including lactam, RCM, disulfide bonds, thioether, and click chemistry
Synthesis of metallo-peptide-chelate and PDC compounds
Comprehensive assays for potency (biochemical and cell-based) and DMPK evaluation
Routine ePSA tests (SFC) for permeability prediction and evaluation
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