BioDuro supports the success of simple and complex peptide drug discovery programs. Our team specializes in process development support for various peptide forms and offers expertise in multiple purification techniques. These peptides include linear, cyclic, branched, and peptide drug conjugates (PDCs).
Expansion of accessible peptide space through flexible length design (4–20 amino acids), diverse architectures, and validated cyclization strategies that support structurally stable and functionally relevant peptide formats
Enhanced chemical diversity through incorporation of 1,000+ unnatural amino acids, enabling precise tuning of peptide properties such as stability, permeability, and binding affinity
High library fidelity enabled by high-quality oligopeptide building blocks, supporting reliable library construction and hit identification
Accelerated hit validation through integrated high-throughput synthesis and Direct-to-Biology (D2B) workflows
Conversion of DEL-enriched sequences into testable peptide candidates
High-throughput, plate-based parallel synthesis
Direct-to-biology functional screening without purification
Applicability across diverse peptide modalities and chemistries
Rapid validation and prioritization of hit series
Seamless transition toward PCC-ready candidates
AI assisted virtual screening (by Atombeat): Rapid filtering based on key developability traits such as membrane permeability, advancing only the most promising compounds
High-throughput synthesis: Parallel production of hundreds of peptides within one week
Without purification steps: High-purity peptides delivered directly
Seamless to biology: Direct transition from in silico design to biology assays for rapid validation
Over 17 years of extensive experience in peptide chemistry, including both solution and solid-phase synthesis
In-house synthesis of unnatural amino acids, ranging from gram to kilogram scale, using robust methods
Expertise in backbone and side chain modification of peptides
Synthesis of macro cyclopeptides with diverse structures, including lactam, RCM, disulfide bonds, thioether, and click chemistry
Synthesis of metallo-peptide-chelate and PDC compounds
Comprehensive assays for potency (biochemical and cell-based) and DMPK evaluation
Routine ePSA tests (SFC) for permeability prediction and evaluation
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