Surface Plasmon Resonance (SPR)
Overview of Surface Plasmon Resonance (SPR) for Biologics and NCEs
Surface plasmon resonance (SPR) is a core biophysical technique, supporting label-free analysis of biomolecular interactions using changes in refractive index at the sensor chip surface. This advanced biophysical technique measures how molecules bind and dissociate, providing insight into kinetics, affinity, and binding stoichiometry. It supports the drug discovery process for both
small molecules and
biologics.
Our Shanghai site is equipped with the Biacore™ 8K—an advanced SPR system engineered for high-throughput analysis in large-scale studies. By monitoring molecular interactions in real time, we help predict in vivo behavior and identify viable drug candidates earlier in the development cycle.
Highlights
The Biacore™ 8K platform delivers industry-leading sensitivity and throughput, supporting detailed kinetic analysis for a wide range of targets.
Our scientists conduct competitive
binding assays and screening. Our surface plasmon resonance services deliver high-quality data across the drug discovery continuum—from early screening to lead optimization and late-stage validation.
BioDuro’s SPR analysis offers:
Association and dissociation rates – The speed at which molecules bind or dissociate
Binding stoichiometry – The ratio of molecules involved in the interaction
Specificity analysis – The ability of a ligand to selectively bind its intended target
This level of insight supports faster decision-making and more informed therapeutic development.
SPR for Drug Target Interactions
Compound binding affinity
Full binding kinetics and binding stoichiometry
Residence time
Fragment library screening
Affinity Maturation
Hot Spot Analysis/Stress Test
Fc Engineering
Anti-drug Antibodies (ADA)
Epitope Binning/Mapping
BsAb Construction
CAR-T scFv Screening and Selection
Antibody-Drug Conjugate (ADC)
Epitope Mapping
IND Package
Specificity Study
Cross-Reactivity
FcRn
FcγRs
C1Q
SPR for NCEs
Compound binding affinity
Full binding kinetics and binding stoichiometry
Residence time
Fragment library screening
Why Choose BioDuro for SPR Services?
BioDuro combines deep expertise in surface plasmon resonance with a broader drug discovery platform, including
medicinal chemistry,
discovery biology,
DMPK, and
pharmacology. Our team supports projects from early-stage research through IND submission, integrating SPR with complementary assays to accelerate timelines.
With Biacore™ 8K, we offer fast turnaround times and precise data, even for weak or transient interactions. We provide both standard assay formats and fully customized solutions tailored to specific research goals and molecular targets.
Clients benefit from flexible assay design, expert consultation, and rapid access to the data needed for critical development decisions.
Contact Us
BioDuro delivers customized solutions for diverse pharmaceutical R&D challenges. Whether you’re screening early-stage hits or preparing for clinical trials, our SPR services provide the accuracy, speed, and insight needed to move forward with confidence.
Contact us today to request a consultation or a project quote. Submit a request through our online form, and a member of our team will be in touch shortly.
Q&A
What is SPR used for in drug discovery?
SPR measures biomolecular binding events—such as affinity, kinetics, and stoichiometry—without requiring labels. This allows researchers to study molecules in their natural state and make more accurate predictions about in vivo performance.
How does the SPR service support biologics and small molecule research?
Using the Biacore 8K platform, we can analyze complex biologics and small molecules with exceptional sensitivity. Our capabilities include fragment screening, ADA detection, affinity maturation, and Fc receptor binding—all of which support different phases of therapeutic development.
What are the advantages of using SPR in drug development?
SPR offers kinetic resolution, label-free interaction analysis, and exceptional specificity of biomolecular interactions, enabling more efficient lead identification and optimization. This helps researchers understand interaction dynamics and binding strength with precision.
Can BioDuro customize SPR assays for specific research needs?
Yes—we develop tailored SPR assays based on your molecular target, binding characteristics, and research objectives. Our scientists work with you to optimize assay conditions for reliable, actionable results.
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