UPCOMING WEBINAR
Accelerating Hit Discovery for Hard-to-Target Proteins: A Fragment Library Approach Applied to MyD88
Fragment-based drug discovery (FBDD) offers an efficient route to explore chemical space, but critical bottlenecks remain. Commercial fragment libraries are either too large to screen routinely with biophysical methods or too small to capture sufficient chemical diversity for challenging targets. The path from fragment hits to leads demands extensive medicinal chemistry iterations with limited guidance on the most promising directions. Moreover, fragment expansions into focused compound collections lacks streamlined, integrated computational and experimental workflows, leaving a persistent gap between primary screening hits and lead series.
