DNA-Encoded Library (DEL) Screening Services
Advanced DNA-encoded library (DEL) small molecule drug discovery screening services
BioDuro and X-Chem have partnered to provide DEL services since August 2022
High quality lead-like/drug-like focused libraries incorporating state-of-the-art DEL design and synthesis
Thorough protein QC and AI-powered comprehensive DEL selection data analysis
Hit structures with embedded SAR information provided to clients who are offered full freedom to operate
Transparent cost structure, no downstream financial obligations
Unmatched track record for DEL-driven hit identification by X-Chem, backed by comprehensive Discovery services (Chemistry, Biology, DMPK, Pharmacology) to rapidly advance clients’ discovery programs
DEL Screening Services Overview
BioDuro is an exclusive strategic partner of X-Chem in China. X-Chem is the leader in small molecule discovery science, providing pharmaceutical and biotech companies a complete, seamless solution for screening, hit validation and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, X-Chem has been leading the DNA-encoded library (DEL) field for more than a decade, delivering over 90 programs to the partners and clients, comprising over 1,000 novel, validated hit compounds across more than 30 different target classes.
Peptide DNA-Encoded Libraries (Peptide DEL)
Why Peptide DEL
Peptide discovery requires efficient exploration of vast and chemically diverse sequence space, which is difficult to achieve with conventional synthesis approaches. While display technologies such as phage and mRNA display enable high-throughput screening, their reliance on biological translation limits chemical diversity.
DNA-encoded library (DEL) technology helps address these challenges by enabling large-scale, chemically flexible peptide discovery.
Explore the full Peptide DEL platform overview
Why Peptide DEL
While DNA-encoded library (DEL) technology enables scalable peptide discovery, its application remains constrained by limited peptide length, restricted structural diversity, and challenges in maintaining library quality.
BioDuro’s Peptide DEL platform is designed to address these limitations through an integrated approach that combines:
Expansion of accessible peptide space through flexible length design (4–20 amino acids), diverse architectures, and validated cyclization strategies that support structurally stable and functionally relevant peptide formats
Enhanced chemical diversity through incorporation of 1,000+ unnatural amino acids, enabling precise tuning of peptide properties such as stability, permeability, and binding affinity
High library fidelity enabled by high-quality oligopeptide building blocks, supporting reliable library construction and hit identification
Accelerated hit validation through integrated high-throughput synthesis and Direct-to-Biology (D2B) workflows
Together, these design and construction strategies enable robust library generation for downstream screening, efficient exploration of peptide chemical space, and rapid identification of structurally complex, functionally relevant hits.
DEL Screening and Hit Identification Workflow
BioDuro applies a selection-driven DEL workflow to identify target-binding peptide motifs from large and diverse libraries.
Peptide DEL libraries are incubated with the target protein, followed by removal of non-binders and elution of bound sequences. Iterative selection cycles (typically 2–3 rounds) enable progressive enrichment of target-specific binders, which are then decoded through DNA sequencing for hit identification.
See how this workflow is applied in real discovery programs
From DEL to Direct-to-Biology (D2B) Hit Validation
Following DEL screening, enriched sequences are advanced into Direct-to-Biology (D2B) workflows for functional validation and hit prioritization.
Conversion of DEL-enriched sequences into testable peptide candidates
High-throughput, plate-based parallel synthesis
Direct-to-biology functional screening without purification
Applicability across diverse peptide modalities and chemistries
Rapid validation and prioritization of hit series
Seamless transition toward PCC-ready candidates
The BioDuro Advantage
X-Chem’s versatile DEL screening is proven in projects spanning numerous target classes. The robust process has been highly successful against targets considered difficult or even intractable
Protein-protein interactions
Ubiquitin ligases
Epigenetic targets
G protein-coupled receptors
Bacterial enzymes
Services
The platform, libraries and screening strategies are designed to generate compound classes that can address any target and modality
Lead-like compounds
Drug-like compounds
Macrocycles
Peptides
Covalent inhibitors
Protein degraders
Allosteric inhibitors
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