Expanding Peptide Drug Discovery with Next-Generation Peptide DELs

Peptide therapeutics offer highly specific and versatile treatments for complex and previously undruggable targets. High-throughput peptide library screening has accelerated discovery. However, traditional platforms such as phage or mRNA display are inherently limited by biological translation processes. DNA-encoded library (DEL) technology provides an alternative, enabling incorporation of unnatural amino acids and diverse cyclization strategies, and producing peptides with improved stability and prolonged retention.

 In this webinar, Dr. Yihui Xie will discuss the challenges and innovations in peptide DEL design. Topics include moving beyond small-molecule–oriented chemical space, prioritizing peptide topology and conformational diversity, rational library-level design for better bioavailability and solubility, chemical strategies to improve on-DNA peptide purity, functional and cellular assays for expanded screening, and the integration of AI for data-driven discovery.

 We encourage peptide researchers, DEL practitioners, and AI scientists to join Dr. Yihui Xie on Mar 31. Attendees will gain insights on how peptide DELs can accelerate drug discovery and complement virtual libraries, providing practical strategies for peptide therapeutic development.

What you will learn:

·        How to overcome key challenges in peptide drug discovery

·        The latest advancements in peptide DEL technology

·        Opportunities and strategies with next-generation peptide DELs

·        Innovative approaches driving peptide DEL programs forward

Register Now

Speaker:

Dr. Yihui Xie, Ph.D.

Director of Peptide Chemistry, 

BioDuro