Peptide Drug Discovery Overview
At BioDuro-Sundia, we leverage decades of experience and expertise in
peptide chemistry to deliver high-quality peptides, from milligram to gram scales. Our state-of-the-art facilities, including a dedicated 1,500 m² peptide synthesis center in Beijing, are equipped with top-class instruments and supported by a team of 100+ experienced chemists.
Click here to download the PDF version of our peptide synthesis services flyer. Peptide DNA-Encoded Libraries (Peptide DEL)
Why Peptide DEL
Peptide discovery requires efficient exploration of vast and chemically diverse sequence space, which is difficult to achieve with conventional synthesis approaches. While display technologies such as phage and mRNA display enable high-throughput screening, their reliance on biological translation limits chemical diversity.
DNA-encoded library (DEL) technology helps address these challenges by enabling large-scale, chemically flexible peptide discovery.
Explore the full Peptide DEL platform overview
Why Peptide DEL
While DNA-encoded library (DEL) technology enables scalable peptide discovery, its application remains constrained by limited peptide length, restricted structural diversity, and challenges in maintaining library quality.
BioDuro’s Peptide DEL platform is designed to address these limitations through an integrated approach that combines:
Expansion of accessible peptide space through flexible length design (4–20 amino acids), diverse architectures, and validated cyclization strategies that support structurally stable and functionally relevant peptide formats
Enhanced chemical diversity through incorporation of 1,000+ unnatural amino acids, enabling precise tuning of peptide properties such as stability, permeability, and binding affinity
High library fidelity enabled by high-quality oligopeptide building blocks, supporting reliable library construction and hit identification
Accelerated hit validation through integrated high-throughput synthesis and Direct-to-Biology (D2B) workflows
Together, these design and construction strategies enable robust library generation for downstream screening, efficient exploration of peptide chemical space, and rapid identification of structurally complex, functionally relevant hits.
DEL Screening and Hit Identification Workflow
BioDuro applies a selection-driven DEL workflow to identify target-binding peptide motifs from large and diverse libraries.
Peptide DEL libraries are incubated with the target protein, followed by removal of non-binders and elution of bound sequences. Iterative selection cycles (typically 2–3 rounds) enable progressive enrichment of target-specific binders, which are then decoded through DNA sequencing for hit identification.
See how this workflow is applied in real discovery programs
From DEL to Direct-to-Biology (D2B) Hit Validation
Following DEL screening, enriched sequences are advanced into Direct-to-Biology (D2B) workflows for functional validation and hit prioritization.
Conversion of DEL-enriched sequences into testable peptide candidates
High-throughput, plate-based parallel synthesis
Direct-to-biology functional screening without purification
Applicability across diverse peptide modalities and chemistries
Rapid validation and prioritization of hit series
Seamless transition toward PCC-ready candidates
AI Empowered Peptide Discovery
Empowered by Atombeat’s Hermite® software and RiDYMO® platform, enhanced by Reinforced Dynamics, Uni-Dock, Uni-FEP, and Uni-QSAR, we can explore over one trillion peptide compounds built from more than 1,000 natural and non-natural amino acids.
AI assisted virtual screening (by Atombeat): Rapid filtering based on key developability traits such as membrane permeability, advancing only the most promising compounds
High-throughput synthesis: Parallel production of hundreds of peptides within one week
Without purification steps: High-purity peptides delivered directly
Seamless to biology: Direct transition from in silico design to biology assays for rapid validation
Discovery Peptide Chemistry
Our broad peptide synthesis capabilities support a variety of peptide catalogs including linear, cyclic, modified, and conjugated peptides.
Linear Peptide
Expertise: Linear peptide with up to 70 amino acids, including hindered unnatural amino acids
Fast Delivery: a typical turnaround time of 5 days for peptide with 40 amino acids
Versatile Salt Forms Available: including TFA, acetate, and HCl
Cyclic/Macrocyclic Peptide
Lactam cyclic peptide
Thioether-cyclized peptide
Stapled peptide
Multiple disulfide bonds
Click peptide
Cyclic lipopeptide
Modified Peptide
Dye and fluorescent labels
Glycosylation
Phosphorylation
N-terminal modification
C-Terminal modification
Special Peptide
Hydrophobic sequence
Cell-penetrating peptide
PEGylated peptide
Lipidation
Peptidomimetics
Peptoid
Depsipeptide
Peptide Conjugate
Metal chelating conjugate (RDC)
Peptide drug conjugate (PDC)
Typical Peptide Delivery Cycle Time (<100 mg)
Automatic Peptide Synthesizers
Case Studies in Macrocyclic Peptide Synthesis
Cutting-edge Kilogram-scale Peptide Scale-up Capabilities
Solid-phase Peptide Synthesis (SPPS) up to 800 mmol, enabling efficient production of linear peptides, cyclic peptides, and various peptide drug conjugates (PDC)
Liquid-phase Peptide Synthesis (LPPS) capabilities also available to support seamless scale-up and ensure efficient project delivery
Other In-House Capabilities to Empower Your Innovation
Our
Discovery Biology department provides a comprehensive suite of capabilities, including cell-free assays, cellular assays, and in vivo efficacy models, ensuring accurate and reliable data to support research.
Our
DMPK department offers comprehensive services, rigorously screening candidates to optimize drug-like properties and accelerate development timelines.
Our
Formulation department leverages expertise in enteric coating and permeation enhancement technologies to help enhance the bioavailability and efficacy of oral peptide delivery.
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