Accelerating PROTACs and RIPTACs Programs: From Synthesis to In Vitro Profiling

Want to speed up early discovery of PROTACs and RIPTACs? These heterobifunctional molecules move beyond classical occupancy-driven inhibition to event-driven modulation of protein function, enabling therapeutic targeting of proteins that were previously considered undruggable. This webinar demonstrates how chemical synthesis and in vitro profiling can be combined to rapidly generate, optimize, and advance these molecules in early discovery programs.

In the chemistry session, we'll cover strategies for efficiently synthesizing PROTACs and RIPTACs, separating isomers, and tuning linkers, warheads, and E3 ligase ligands. A case study of a recently synthesized RIPTAC illustrates how rapid synthesis and careful characterization enabled its use in both in vitro and in vivo testing. Practical considerations for Molecular Glues synthesis will also be highlighted.

The biology session focuses on in vitro profiling, including degrader assays for PROTACs and proximity-based assays for RIPTACs. Participants will see how assay data can guide compound prioritization and inform early discovery decisions.

Whether you're starting a new induced proximity program or looking to accelerate an existing one, join us to see practical strategies in action — register now to reserve your spot!

What you will learn:

Strategies for efficiently synthesizing and optimizing PROTACs and RIPTACs, including isomer separation and tuning linkers, warheads, and E3 ligase ligands

Key lessons from real-world discovery projects to overcome common synthesis challenges

How in vitro assays are used to characterize compounds and support optimization

How biological insights enable effective screening prioritization and faster decision-making

Case studies showing how chemistry and biology combine to accelerate RIPTACs and PROTACs discovery

Register Now

Speakers:

Yanchun Guo, Ph.D.

Director of Discovery Biology, 

BioDuro

Xingao Peng, Ph.D.

Senior Director of Chemistry

BioDuro