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New year, new advancements for the industry's oldest and most beloved dosage form? lt's likely, according to experts. Not surprisingly, industry leaders predict a continued focus on improved adherence via user-friendly dosage forms and designs in both the pharma and nutraceutical spaces. Users want delivery formats that not only work with their lifestyles but are enjoyable. As Juliana Erickson, global product innovation manager for Lonza Capsules & Health Ingredients puts it, look for a “prioritization of pleasure” in 2025.

Technology will also be key to OSD's future, with advancements in automation, continuous manufacturing and 3D printing helping manufacturers respond to shifting patient demographics and needs. Better equipment efficiency and accuracy will enable manufacturers to stay on top of necessary cost-saving initiatives.

Quality will remain ever-important, as manufacturers continue to wrestle with nitrosamine impurities. On the nutraceuticals side, manufacturers will square off against pharma-level accountability and requirements. And 2025 may be the year that OSD gets in on the weight-loss market frenzy, as new innovations enable manufacturers to overcome bioavailability challenges of oral biologics. Here's a look at what industry leaders in pharmaceuticals and nutraceuticals are predicting for the coming year.

Patient/Consumer-Friendly Delivery Formats

＞Tom Sellig, CEO, Adare Pharma Solutions

The OSD landscape is set to witness transformative advancements in 2025 and beyond. High-potency drugs, driven by oncology and specialized therapies, will continue to dominate development pipelines. This highlights a critical shift toward addressing complex and niche diseases. Despite challenges in bioavailability and stability, ongoing innovations in oral formulations for obesity treatments promise expanded access and adherence for patients. Additionally, 3D printing technology will redefine what is possible in OSD. From multidrug tablets to customized release profiles, 3D printing offers unparalleled flexibility, paving the way for personalized medicine. Finally, patient. Centric dosage forms will continue to gain prominence. Innovations such as sprinkle formulations, orally disintegrating tablets, and transformative dosage forms will ensure better adherence for diverse patient populations, including pediatric and geriatric groups. Dosage forms that prioritize flexibility, convenience and accuracy will play a pivotal role in improving patient quality of life. As we enter 2025, these trends underscore a patient-focused and technologically sophisticated future for OSD.

＞Bhavishya Mittal, Ph.D., VP, Product Development and Manufacturing, BioDuro

Better understanding of disease mechanisms has helped bring new therapies to market, but in 2025 and beyond, more active participation of patients is required to achieve safe and effective drug regimens. Up to 30% of U.S. healthcare spending is wasted due to poor patient adherence. Product design improvements that lead to better adherence can improve outcomes and potentially save billions in healthcare costs. With patient usage issues such as multi-morbidity incorporating patient-centric dosage form design concepts can add value to the product early on. Product design teams must comprehensively assess patient characteristics such as disease conditions, disabilities, impairments and specific needs, and incorporate those factors early into product development.

To enhance compliance, we at BioDuro see increasing adoption of oral modified-release formulations in early development, particularly for high-dosing frequency drugs. From a business perspective, incorporating patient-centric design allows companies to differentiate themselves from the competition and make products more desirable.

＞Céline Zuber, Manager, Global Marketing and Communications, Health, Nutrition & Care, dsm-firmenich

Patient-centric innovation focused on safety, convenience and compliance, will shape the future of drug development. In view of safety, nitrosamine risk mitigation strategies are necessary for potential reformulations and new drug formulation to comply with updated guidelines. Here, ascorbic acid and other nitrite scavengers have demonstrated their role as functional excipients, reducing nitrosamine formation by blocking nitrosation reactions. With growing pill fatigue, polypharmacy, and over 60% of Apls being inherently bitter, the demand for more patient-friendly dosage forms that support compliance and accommodate Ulti-AP| combinations, is on the rise too. Flavoring agents, including maskers and bitterness blockers, have become an essential tool in pharmaceutical formulation to improve the palatability of medicines. Additionally, formulations that enable higher drug loading and optimized bioavailability could help lower dosage frequency and minimize adverse events, helping patients adhere to their prescribed treatments. This would be revolutionary in the case of cannabidiol-based medications for instance.

＞Juliana Erickson, Global Product Innovation Manager, Lonza Capsules & Health Ingredients

Consumers are demanding more from nutraceutical supplements than efficacy alone-they are seeking enjoyable and experiential delivery formats that elevate their daily routines. Lonza's proprietary research reveals 70% are willing to pay more for a more enjoyable, memorable supplement experience. This aligns to a key trend for 2025: the prioritization of pleasure.

Going beyond a product's ingredients to captivate consumers through scents and flavors is one way that brands can meet consumer needs and stay ahead of the competition. Next-generation capsules enable the creation of multi-sensory experiences associated with consumers holistic health. By combining exceptional delivery systems with scented supplements, brands can develop truly holistic products that bridge the gap between sensory perception and nutritional supplements. This 360-degree experience unlocks a new frontier in supplement innovation, catering to a wider range of consumers-particularly those seeking a more enjoyable and engaging approach to wellness

＞Ketaki Patwardhan, Global Technical Developer, Roquette

Patient-centric considerations, such as improving ease of use, adherence, and overall user experience remain the main forces shaping the future of oral dosage forms. That being said, environmental concerns are becoming increasingly influential as regulators and end users push brands to adopt greener, more responsible drug manufacturing practices. There's an opportunity here for producers to improve their environmental credentials through the adoption of biodegradable and renewable plant-derived polymer excipients in place of synthetic materials. Modified starches for example, are not only kinder to the environment, but are paving the way for more effective drug delivery systems through the creation of smaller, easier-to-swallow pills. Implementing streamlined production processes, like continuous manufacturing, can also help minimize waste and energy consumption and maintain product quality, safety and efficacy. In 2025, expect to see the pharma industry work to embrace this dual challenge of prioritizing sustainability, while ensuring patient needs are kept front and center.

＞Shahrzad Missaghi, Ph.D., Senior Manager Product Development, Colorcon

Oral solid dosages are projected to grow steadily in 2025and beyond, given ease of administration and increased patient compliance. increasing population and longer lifespans contribute to this growth. The following trends are expected to shape the ongoing evolution of OSD toward safer, more efficient, personalized and advanced treatment options for patients: Oral delivery of macromolecules and biologics, including orally ingestible devices and long-acting OSD are gaining momentum as innovative platforms, Increased adoption of digitalization and data driven approaches, including Al for discovery, formulation, manufacturing and clinical trials - which all lead to accelerated drug development, Enhancement of solubility and bioavailability of poorly soluble drugs remains an area of focus, with novel technologies to address the unmet needs, Continuous manufacturing and additive manufacturing, along with precision medicine, continue to bring innovation into the industry, Greater emphasis on sustainable manufacturing practices reduces environmental impact.